Japan produce can replicate human disease of fluorescent monkeys

Recently, Japan scientists announced that they have developed the world's first can replicate human diseases and glowing primates genetically modified.

In a gene's help, they let the marmosets bred skin green strand due to "copy" of humanity is suffering of some of the most devastating diseases, laboratory for the study of these monkeys is undoubtedly the cause of the disease and the treatment provides a completely new model. Japan research group said: "the use of these models, the incubation period is expected to make a series of great breakthroughs. "But other people also warned that Japan scientists could potentially trigger a" moral crisis ". These people are concerned that this kinship with in our most recent "relatives" technology can be used to cultivate genetically modified. A Keio University Center for the study of Sasaki laboratory animals? {RI (Erika Sasaki) led a research group reported on common marmosets (Brazil originating from one of the world's smallest long-tailed monkey) results. The experiment, they introduced a foreign gene (implantation of a virus) and injection marmosets embryos, after that, their cultivation in sucrose solution in embryos. This gene carrying green fluorescent protein, green fluorescent protein is a first from jellyfish in segregation of a substance, it is usually used as bio-tech industry of an indicator. In ultraviolet light exposure, carriers of green fluorescent protein in animal have a green light, proved a key gene sequences have been "connected". Transgenic embryos are then implanted 7 only surrogate marmosets uterus. 3 the "surrogate mother" the unfortunate abortion, and the last four birth 5 tiny marmosets and are carrying green fluorescent protein gene. Where 2 little marmosets, green fluorescent protein gene and germ cells. These two successful experiment in a subsequent initiation of second-generation marmosets. Japan scientists work with very important, reason is: medical researchers have been eager to gain respect and human anatomy is similar than rodents in animal models. Genetically modified mice to exhibit symptoms of human disease, is the backbone of the incubation period of laboratory research. The incubation period of the study, scientists first to test their theory, then in human volunteers, who validate the results of the experiment. But many diseases — especially including Alzheimer's disease and Parkinson's disease, diseases of the nervous system — as too complex to be in biology and the enormous difference of human existence rodents on the "copy". Prior to this, a non-human primates model attempts to have ended in failure, researchers cannot be gene implantation monkey sperm and eggs, these two kinds of germ cells can ensure that implantation of DNA (Inserted DNA) to the next generation and not disappear.

The first transgenic monkey was born in 2000, called "Andy" (ANDi, "Inserted DNA," abbreviation of the around).

This rhesus monkeys also carry a green fluorescent protein, but not in its germ cells. Japan scientists make of this latest achievement is the cultivation of inherited human diseases have copied this characteristic of transgenic cloning primates "infants" opened the door of hope. Future research projects including the cultivation of transgenic marmosets, replication Parkinson and spinal muscular atrophy of ALS patients and other human diseases. United Kingdom company is responsible for monitoring gene research ethics issues of non-governmental organizations--United Kingdom gene observed Helen · Wallace (Helen Wallace) said: "many problems still don't get the answer. From nurturing a can of green fluorescence to cultivate a marmoset can replicate human disease of marmosets is indeed a great breakthrough, but there is still a more complex things waiting for it to complete. Such research will inevitably raises a very important ethical controversy, contention, first is the animal itself, followed by what may in the future, as well as the cultivation of genetically modified people whether moral and ethical. ”