Molecular diagnosis of entering a new era of rapid development

New technologies are emerging

As the human genome project's successful completion, an increasing number of genomic and proteomic information is used to serve and clinical diagnosis related experimental work, assume this information analysis of microarray technology is also emerging.

Cheng Jing in the bio-chip diagnostic technology "report describes the biochip technology. In the sample preparation, are now available on the chip through a variety of active function devices, on body fluids in the molecular and cellular for fast and effective separation, the next step of biochemical reactions.

In addition, on the chip for gene amplification reactions have also been achieved in microarray chip area, single nucleotide polymorphism (SNP) and mutation analysis of chip, comparative genomic hybridization chip and other high-density microarray chip that was used to discover and disease-related biomarkers, integration of various features on-chip laboratories is also about to step into the industrialization stage.

"Biochip technologies and the rapid development of people to behold, they come out of the disease early-warning and intervention, personalized diagnosis and prognosis, has opened up a broad application prospects.

"Journey to Beijing.

An endless stream of new results

Molecular diagnosis of technology is becoming a life sciences innovative activity in the field of research, our scientists in the field of innovations and continuously made, leading the Chinese molecular diagnostic technology forward, overtaking and beyond.

Larry Kricka academician describes international molecular diagnosis technology of the latest research results and development trends.

Academician, President of Sun Yat-sen University Cancer Hospital had IK new stressed that cancer is a gene involved in multiple, multiple signaling pathway of many diseases, cancer early diagnosis and early warning on high risk populations, to improve cancer cure rates, lower mortality rates has a very important significance, molecular diagnosis technology will play an important role.

Academician, Central South University national key discipline Chair Professor of Pharmacology, honghao microarray development speed significantly surpassed the expected individual human beings, drug use will build on the chip technology from candidate genes to the genome of leap.

Central South University has several areas in the country will pharmacogenomics and Genetic Pharmacology knowledge into clinical practice for the safety of medication use and individualized medicine provides a strong support.

Nicpbp researcher Wang Jun Chi explains, after years of efforts, pharmaceutical and biological products has developed pathogenic microorganisms class diagnostic reagents to detect with the standard 53, in the past few years major communicable diseases control and prevention (CDC) has played an important role.

Zhuang Hui, Peking, academician, Chinese Academy of Sciences academician biological physics, chenrunsheng, Shenzhen huada gene Research Institute Yang Leo fellows, the PLA general hospitals pay Xiaobing, academician, respectively describes hepatitis diagnosis, non-coding RNA and molecular diagnosis of the research progress.

Cheng Jing said: "we and the international gap is small, there is a technical original great expansion space.

Through our efforts, we can quickly catch up. ”

New products are applied

Our molecular diagnostic technology development has been in service for the diagnosis and treatment of clinical disease.

In recent years, the State food and Drug Administration (SFDA) have ratified a hereditary hearing loss gene chip, Mycobacterium tuberculosis identification of gene chip and resistant gene chip, etc for clinical testing, marking the molecular diagnostic technology is becoming a clinical laboratory medicine in China an important force.

The PLA General Hospital of Otolaryngology-Head and neck surgery Professor Dai Park, in the full access to the national large-scale groups of deaf deafness mutation type and frequency, on the basis of diagnosis for the development of deafness genes provide system and platform, Boao bio company and the PLA General Hospital specifically chose the nine most common deafness gene mutation, successfully developed based on the allele-specific PCR universal chip (ASPUA) platform deafness gene chip technology and products, is currently directed at Chinese deaf groups most effective detection and screening tool; promote large-scale screening for disease genes and pre-natal diagnostic techniques for genetic counseling and intervention to reduce the systemic deafness birth defects and the incidence of drug-induced hearing loss, to improve the quality of our birth.

The first affiliated hospital of China Medical University, Vice President, the Ministry of health HIV immunology laboratory director Professor still red, at present, in China the nucleic acid detection HIV-1 has gradually throughout the hospital, the Centers for disease control and prevention, and other related sectors and applications, many universities and research institutions to apply the nucleic acid detection methods HIV-1 has launched a variety of basic and applied research, the overall increase in AIDS prevention, diagnosis and treatment.

Guangzhou Guangzhou General Hospital Laboratory Director jade-ling, Professor of the gene chips early detection of Mycobacterium infection: a case analysis of the report describes the principle as therapy, clinical currently are in great need of a simple and rapid method for Mycobacteria for differential diagnosis.

Boao biological development of cellular communication of Mycobacterial species identification Kit (microarray chip method), you can fast and easy diagnosis of infection with Mycobacterium, for clinical diagnosis and rational use of medicines correctly provide a vital basis.