Journal of nuclear medicine: PET/MR can reveal after traumatic brain injury long-term changes in brain

In the November edition of journal of nuclear medicine (JNM), one study results show, PET and MRI-weighted Imaging can help researchers better understand traumatic brain injury (TBI) brain structure and function of long-term change.

　　

Brain MRI + PET scan synchronization

Traumatic brain injury has high chronic neurological disease morbidity and spirituality.

"These study results for post-traumatic brain changes with new insights," Paris University Dr. Viviane Bouilleret neurophysiology, explained that "This indicates that after traumatic brain injury in the brain structure and function will last several months. ”

Study on the use of horizontal liquid blast injury in rats.

In the result, use fluoride after TBI-18-to-oxygen and glucose are sub contrast (18F-FDG PET) and MR complete three-dimensional reconstruction. Researchers in rats after the first, third, June gets image.

Studies on early stages filmed 18F-FDG PET imaging, many brain metabolism slowing down the performance as the partition, whereas in the latter part of the MRI is manifested progressive degeneration, particularly in the cortex and hippocampal volume.

Bouilleret and colleagues found that fluid blast early functional changes will appear in six months after the reduction or even disappeared, and structural changes will continue to develop.

Brain structure and function is dynamic, this change in fluid shock trauma after three to stabilise in June, as we understand TBI patients after nerve and spirit of long-term potential impact mechanism, a new path.

Brain metabolism slowing down earlier than sexual brain atrophy this discovery prompted: brain neural degeneration might partition is a mechanical action.

The author believes that the study is important because it indicates a potential neuroprotective mechanisms reduce fluid shock trauma neurodegenerative changes of secondary.

This study also in burdensome and expensive clinical trials before the future possible treatment methods for bio-availability has been validated.

"This approach also applies to other neurological diseases such as stroke, dementia, multiple sclerosis, epilepsy, a brain infection, these are the brain chronic degenerative changes of the study," Bouilleret said.