Cancer gene "switch" for the first time synthesis can control tumor growth

You can control the cancer gene switch first synthesis of molecules

Treatment for cancer are expected to bring a completely new method

In order to prevent the spread of the tumor growth, scientists from various channels.

United Kingdom United States Association for the advancement of science, the journal nature reported that United States Web site recently reached the · method Bo Cancer Institute an international joint research team developed a molecule that can control the cancer gene instructions fail, fundamentally inhibits the growth of cancer tumors.

New study demonstrates a protein can be issued to the cancer gene "stop" and "start" command, this protein is the apparent protein gene "read", it is the aim for the future of cancer treatment.

In recent years, control the behavior of the cancer gene has a great development, methods of controlling gene switch evident result of cancer treatment.

Paper up to the main authors, Bo Cancer Institute · law · PreK-e James said, if you can turn off a cancer cell growth genes, cells will be killed. On the contrary, if you open a normal tissue gene that makes cancer cells become normal tissue cells.

Their research is a rare but highly aggressive form of cancer that children and Youth Center cancer testis nucleocapsid (NMC), this is a fully defined by the genetic characteristics of the disease — BRD4-NUT gene translocations.

This cancer is very stubborn, usually in the chest, head, neck, along the vertical centerline of the parts of the body, the clinic is no effective treatment method. Chemotherapy is only effective in the short term and, ultimately, does not prevent the spread of the tumor.

NMC cancer is caused by chromosomal "transposition", two from different chromosomes genes together, this exception is called the combined protein BRD4-NUT.

Cell gene directive is like a kind of "bookmarks", chromatin substrate of apparent gene is "writing" protein, another group of apparent gene can be compared to the Eraser, known as "MOCA" protein that can clear the bookmark.

While the three apparent gene, is a way to "read" the directive "bookmark" the protein, thereby controlling gene switch, this is what researchers aim at the target.

Scientific literature points out that certain stabilization class drugs such as diazepam (Valium), Pu-based cartridge (Xanax) and half of collateral Essex (Ativan), able to reduce the effectiveness of BRD4.

On this trail, PreK-e and another researcher qijun (transliteration) developed a series of elements, and observe whether they can inhibit BRD4-NUT gene in "reading" protein.

As a result, there is a combination of molecular it, researchers named JQ1.

This Assembly of molecules is a set of assembled genomic "apparent", can affect the cells of the multi-tiered mechanism to control gene activity. It combines two functions: one is locking the NMC cancer cells in the abnormal protein and let them stop differentiation replication, "forget" their own cells, gradually returns to normal cells.

They were from patients to NMC cancer cells transplantation laboratory mice, and given a number of mice used JQ1 molecules.

PreK Dena said, the effect is very clear that all accepted JQ1 molecular therapy in mice have survived, but useless JQ1 are dead.

Currently, qijun and his team are reversing the molecular shape to play its most powerful.

PreK Dena also noted that, due to be transferred to cancer-causing protein molecule selectively, let them stop cancer program, the side-effects are minimized. Development of molecular JQ1 or this class of drugs that can cause the first designed for NMC design of individualized treatment for patients, cancer treatment will also bring a new approach.