Academician microarray technology: human health Scout (1)

News articles relevant to the c.d "excellent performance the audience an unforgettable impression, people to this beautiful dancer is deaf and sad.

Two-year-old, streptomycin injection due to the high fever news articles relevant to lost hearing. Science and technology development to today, with the microarray technology, like her "a needle induced hearing loss" is completely avoidable.

"If the news articles relevant to the just born do microarray detection, that they are drug-induced hearing loss gene carriers, as long as the future does not use the aminoglycoside drug, you can avoid the incidence of drug-induced hearing loss.

"In Beijing Zhongguancun life science park, 47-year-old Academy Dr Cheng Beijing told reporters. Cheng, academician of the National Engineering Research Center for bio-chip Beijing and Boao biological co., Ltd. (hereinafter referred to as "Boao bio") Center Director and Technical Director, and is also Professor of Tsinghua University School of medicine, Professor of Changjiang scholars of the Ministry of education.

Hereditary hearing loss gene chip is a bio-chip.

Simply put, the bio-chip is a fingernail-sized glass, silicon chip, materials such as nylon membrane on biological probes, it first to be discovered, then the sample response and reaction results related to signal to the collection, then use a computer or other method of analysis of the data results. In 1997, Fortune magazine has reported that "in the history of science and technology of the 20th century there are two things: a far-reaching is microelectronics chip, it is a computer and many of the ' heart ' of household appliances, changed our economic and cultural life, and have access to every family; another is the bio-chip, it will change the way of life science research, innovations in medical diagnosis and treatment, significantly improve the quality and health of the population. ”

Cheng, academician, biochips's role is to help achieve the disease early warning, prevention, and individual treatment.

It is a testing tool, much as appearances are like sensors, computer chips, fixed live different biological materials or biological molecules, biomolecules with these, you can on the biological samples (blood, urine, sputum, etc.) target for testing. By using normal sample data and testing samples of data comparison, an analysis of whether there are differences, the doctor can under the circumstances the difference of being detected by body suffer from disease. Biochips as Scout, advance the cause of detectives, to some extent, do know thyself. Known as the father of the "DNA" reputation of American Nobel Prize winner James · Watson (James Watson) predicted that in the next 10 years, genetic testing for individuals will become a regular means of disease diagnosis. Doctors can study individual gene sequence, to bring the bad genes of those medical recommendations, thereby more effective in the treatment of mental illness, cancer, diabetes, and other complex diseases.

Bio-chip can be used for the diagnosis of hereditary diseases.

Species in China, hereditary diseases, only monogenic 4,000 variety. The disease prevention and early intervention is important, but previous lack effective means early diagnosis. Hereditary diseases of the root cause is due to normal gene sequence changes, but by gene chip (or microarray a) can the accurate determination of gene sequence change of location and the type of change. Bio-chip can also diagnose infectious diseases and resistance testing, organ transplant, drug screening, mentoring individualized medicine, health and quarantine, judicial expertise, etc.

In the many uses of biochips, people are most concerned about is it on human diseases prevention and diagnosis.

Cheng, said, at present, the bio-chip has entered clinical application, start the benefit of millions of households. Like the deafness news articles relevant to maternally inherited factors lead to belong, but it is estimated that China's annual new deaf children nearly 4 million people, of which half is hereditary deafness. It has been found that multiple gene mutation has been involved in the pathogenesis of the disease, and deafness related gene detection, we need more of the sites, traditional testing techniques such as sequencing are often expensive, complex operations. Bio-chip with integrated, high-throughput, quick and easy, and other characteristics that will help clinicians better solve the problem.

Boao biological and PLA General Hospital, Tsinghua University, such as the cooperation of Central South University has developed a hereditary hearing loss gene chip.

This chip can check out the sensorineural hearing loss and large vestibule syndrome patients, can also detect whether people are drug-induced hearing loss gene carriers. Chinese patients with congenital hearing loss carry mitochondrial mutations in about 5%, and mitochondrial mutations and aminoglycoside drugs drug-induced hearing loss are closely related. All were diagnosed as drug deafness gene mutation carriers will require life-long disabled such as streptomycin, kanamycin, gentamicin and tobramycin and amikacin, neomycin, and so all of the aminoglycoside drugs, otherwise it may cause hearing loss induced by "a needle."

According to Cheng, academician, biochip for ordinary consumers, prices are lower and lower, a bio-chip costs just a few hundred dollars.

Boao creature now has four bio-chip products won the Chinese food and drug administration of the medical device registration certificate, start entering the hospital. With the increased demand for bulk, prices will be cheaper in the future, ordinary people can afford to spend.

Cheng, academician said, before it was expensive, followed by technical inspection means not keeping up with.

For example, one got the infectious disease patients to hospitals, doctors said, eat some antibiotics have a look at the effect again, no change, and now, if I come up with bio-chip, you will know very well what is the patient suffering from, what is the source of infection pathogens, cancer which drugs drug resistance, and can be targeted medication, this would greatly reduce the financial burden on patients, while meeting the purpose of rapid and effective medical treatment.