Our researchers for the first time the "human metagenome" concept

Business Club December 9 rising on 7 December, the world's leading scientific journal nature in the biotechnology Division included the Nature Biotechnology published by Shenzhen huada gene Research Institute ', South main involvement in cooperative research with the construction of human Atlas of functional genome sequence.

The thesis has set a new human genome sequencing standards for future medical research indicates the direction that reflect our genomics in the leading position in the world.

The Research Institute of the Shenzhen huada gene research and have the leading position of the second generation sequencing technologies large genome assembly tool, yanhuang 1 genome (that is, the first Asian personal genome) depth sequencing and stitching, discovered the human genome in addition to the original accepted single nucleotide polymorphism, insertion deletion polymorphism and structural variation, the existence of populations of individual special or even unique DNA sequences and functional gene.

For example, in the study found mainly in the Asian population-specific gene sequences.

The international human genome project, based on European DNA as the reference genome sequence of the reference genome sequences, as at present, the vast majority of human genomics data base.

Over the years, most of the scientific research that each individual's genome is similar to the reference genome, only replace or rearrange the nature of the change. The study as the world's first new genome assembly method, the number of individual classes and individual genome for Mosaic, genome sequence analysis for added that points to the human genome in "or" type of gene variants, which first proposed the "human metagenome" concept, namely the human population genetic sequences.

This study also underlines the innovative education system and preliminary results of personnel training.

Article-by-side first author Robert sharp States and another named author jinxin is South third and fourth of college students, belong to the South — Shenzhen huada gene Research Institute of genome science innovation classmates.